System for genetically treating cardiac conduction disturbances

A - Human Necessities – 61 – M

Patent

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Details

A61M 5/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) A61M 5/32 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2260756

The present invention provides delivery systems for delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered by Applicants' delivery system to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.

L'invention concerne des systèmes d'administration permettant d'apporter un matériau génétique à base de protéines de conduction dans des cellules cardiaques situées dans des zones localisées du coeur de sorte que la conductance dans ces dernières soit améliorée. L'invention se rapporte plus spécifiquement à un système pour apporter des connexines ou des molécules d'acide nucléique codant les connexines dans un site du coeur préalablement identifié par des procédures de cartographie comme présentant des problèmes de conduction. Dans les cas où la conduction est altérée, un matériau génétique sélectionné est apporté, au moyen du système d'administration selon l'invention, aux cellules situées autour de la zone de perturbations, de sorte que les schémas de conductivité globale soient améliorés; dans d'autres cas, un matériau génétique est sélectionné pour ralentir la conduction dans les zones touchées et empêcher l'apparition du syndrome de bradycardie-tachycardie.

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