System for monitoring bacterial tumor treatment

Details System for monitoring bacterial tumor treatment System for monitoring bacterial tumor treatment

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61B 1/00 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12Q 1/37 (2006.01) G01N 21/00 (2006.01) G01N 21/75 (2006.01) G01N 21/76 (2006.01) G01N 33/00 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 31/198 (2006.01) A61K 38/00 (2006.01) A61K 38/43 (2006.01)

Patent

CA 2470411

A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes associated with the bacteria that produce therapeutic agents during the course of treatment, optionally against a background of fluorescence generated by the tumor itself. The method permits visualization of the progress of treatment in live subjects so that treatments can be modified according to their efficacy.

L'invention porte sur un procédé permettant de suivre l'évolution du traitement d'une tumeur chez des sujets, ce procédé utilisant des bactéries qui ont été modifiées pour exprimer une protéine fluorescente. Ce procédé permet également de surveiller l'expression des gènes associés au bactéries qui produisent des agents thérapeutiques pendant le traitement, éventuellement contre un fond de fluorescence généré par la tumeur elle-même. Le procédé permet de visualiser l'évolution du traitement chez des sujets vivants de sorte que ces traitements puissent être modifiés en fonction de leur efficacité.

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