System for rendering substantially non-dissoluble...

Details System for rendering substantially non-dissoluble... System for rendering substantially non-dissoluble...

A - Human Necessities

61

K

A61K 47/32 (2006.01) A01N 25/10 (2006.01) A61K 9/14 (2006.01) A61K 9/70 (2006.01) A61K 31/557 (2006.01) A61K 31/56 (2006.01) A61K 38/21 (2006.01) A61K 38/22 (2006.01) B01J 13/04 (2006.01)

Patent

CA 2231050

The present invention is a method of preparing a system for delivering a bio- affecting agent and the composition prepared thereby. The invention includes forming a solid dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water- soluble polymer, the bio-affecting agent is made available ("bio-available") to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non- soluble drugs and other bio-affecting ingredients.

La présente invention concerne un procédé permettant de préparer un système pour administrer un agent bioaltérant et la composition ainsi préparée. L'invention consiste à former une dispersion solide de l'agent bioaltérant dans un état d'énergie accrue dans un polymère soluble à l'eau, qui est compatible avec l'agent bioaltérant. La transformation de l'agent bioaltérant en un état d'énergie accrue, et sa congélation dans cet état dans un polymère soluble à l'eau, se traduit par la disponibilité (biodisponibilité) d'un agent bioaltérant pour un biosystème lors de la dissolution du polymère. Ce procédé et cette composition se sont avérés extrêmement efficaces pour administrer des produits sensiblement non solubles et d'autres ingrédients bioaltérants.

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