C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2329513
An in vitro system is provided that recapitulates regulated mRNA stability and turnover of exogenous RNA substrates. The system comprises a cell extract optionally depleted of activity of proteins that bind polyadenylate, and a target RNA sequence. This system is used for the identification of agents capable of modulating RNA turnover, as well as agents capable of modulating RNA turnover in the presence of RNA stability modifying agents.
L'invention concerne un système in vitro englobant la stabilité de l'ARNm régulé et le renouvellement de substrats d'ARN exogène. Ce système comprend un extrait cellulaire éventuellement dépourvu de l'activité des protéines se fixant sur le polyadénylate, ainsi qu'une séquence d'ARN cible. On utilise ce système pour identifier des agents capables de moduler le renouvellement de l'ARN, de même que des agents capables de moduler le renouvellement de l'ARN en présence d'agents modificateurs de la stabilité de l'ARN.
Ford Lance P.
Wilusz Jeffrey
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Medicine And Dentistry Of New Jersey
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