System for the determination of molecules altering the...

Details System for the determination of molecules altering the... System for the determination of molecules altering the...

A - Human Necessities

61

K

A61K 38/12 (2006.01) C12N 15/01 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2728142

In a first aspect, cyclic peptides are provided identified as molecules altering the interferon activity, namely, inhibiting interferon response. Moreover, the present invention relates to a transgenic animal or parts thereof and a method for the determination of molecules and compounds altering the function of interferons, in particular, type I and type 11 interferon. In particular, said transgenic animal or parts thereof contain large parts of exogenous chromosomal DNA, namely interferon responsive DNA promoter elements operably linked with a nucleic acid sequence encoding a reporter or marker molecule. These a transgenic animal or parts thereof are useful in the methods according to the present invention.

La présente invention concerne, dans un premier aspect, des peptides cycliques identifiés en tant que molécules modifiant lactivité de linterféron, cest-à-dire, inhibant la réponse de linterféron. De plus, la présente invention concerne un animal transgénique ou des parties de celui-ci et un procédé pour la détermination de molécules et de composés modifiant la fonction dinterférons, en particulier, linterféron de type I et de type II. En particulier, ledit animal transgénique ou des parties de celui-ci contiennent de grandes parties dADN chromosomique exogène, cest-à-dire des éléments de promoteur dADN réactifs à linterféron fonctionnellement liés à une séquence dacide nucléique codant pour une molécule de rapporteur ou marqueur. Cet animal transgénique ou des parties de celui-ci sont utiles dans les procédés selon la présente invention.

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