System, method and apparatus for causal implication analysis...

G - Physics – 06 – F

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G06F 19/12 (2011.01)

Patent

CA 2546869

Described are methods, systems and apparatus for hypothesizing a biological relationship in a biological system. A database of biological assertions is provided consisting of biological elements, relationships among the biological elements, and relationship descriptors characterizing the properties of the elements and relationships. A biological element may be selected from the database and a logical simulation may be performed within the biological database, from the selected biological element, through relationship descriptors, along a path defined by potentially causative biological elements to discern a biological element hypothetically responsible for the change in the selected biological element. The logical simulation may be either a backward logical simulation, performed upstream through the relationship descriptors to discern a hypothetical responsible biological element, or a forward logical simulation, performed downstream through the relationship descriptors to discern the extent to which the perturbation generates the observed change in the selected biological element.

L'invention concerne des procédés, des systèmes et un appareil permettant de poser l'hypothèse d'une relation biologique dans un système biologique. L'invention concerne une base de données d'assertions biologiques consistant en éléments biologiques, en relations entre les éléments biologiques, en descripteurs de relations caractérisant les propriétés des éléments et des relations. On peut choisir un élément biologique dans la base de données et exécuter une simulation logique dans la base de données biologiques, à partir de l'élément biologique choisi, par le biais des descripteurs de relations, le long d'un chemin défini par des éléments biologiques potentiellement causatifs pour identifier un élément biologique hypothétique responsable du changement dans l'élément biologique choisi. La simulation logique peut être vers l'arrière, exécutée en amont par le biais des descripteurs de relations afin d'identifier un élément biologique hypothétique responsable, ou une simulation logique vers l'avant, exécutée en aval par le biais des descripteurs de relations afin d'établir jusqu'à quel point la perturbation génère le changement observé dans l'élément biologique choisi.

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