C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2219807
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.
L'invention concerne des ligands oligonucléotidiques à forte affinité avec des cibles de tissus complexes, en particulier les ligands à l'acide nucléique ayant une capacité de liaison avec les cibles tissulaires complexes. L'invention se rapporte aussi aux procédés qui permettent d'obtenir de tels ligands. Parmi les cibles tissulaires figurent les cellules, les constituants infracellulaires, les ensembles de cellules, les collections de cellules et différentes structures d'ordre plus élevé. On décrit spécifiquement des ligants à l'acide nucléique ayant une affinité avec les globules rouges pâles ainsi qu'avec les glioblastomes et les lymphomes.
Chen Hang
Gold Larry
Jensen Kirk B.
Morris Kevin N.
Stephens Andrew
Gilead Sciences Inc.
Mbm Intellectual Property Law Llp
Nexstar Pharmaceuticals Inc.
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