C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2209665
This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including it associated functional unit, and its target.
La présente application fournit des méthodes pour identifier les ligands d'acides nucléiques capables d'interagir par covalence avec des cibles d'intérêt. Les acides nucléiques peuvent être associés avec diverses unités fonctionnelles. La méthode permet également l'identification des acides nucléiques qui possèdent des activités de facilitation d'après leur capacité à faciliter la formation d'une liaison covalente entre l'acide nucléique, qui comprend l'unité fonctionnelle associée, et sa cible.
Eaton Bruce
Gold Larry
Jensen Kirk
Smith Drew
Wecker Matthew
Gilead Sciences Inc.
Mbm Intellectual Property Law Llp
Nexstar Pharmaceuticals Inc.
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