Systemic administration of colony stimulating factors to...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2669599

The invention relates a method of treating amyloidosis, diseases and disorders associated with amyloid plaque formation, e.g., Alzheimer's disease by increasing tissue resident macrophage activity in an organ or tissue of an animal requiring treatment by systemic administration of a colony stimulating factor. For example, the activity of bone marrow-derived microglial cells in an organ or tissue can be increased by systemic administration of a colony stimulating factor, particularly macrophage colony stimulating factor, either alone or in combination with additional colony stimulating factors, stem cell factors or other compounds capable of treating amyloidosis.

La présente invention concerne un procédé de traitement de l'amyloïdose, des maladies et des troubles associés à la formation de la plaque amyloïde, par exemple, la maladie d'Alzheimer en augmentant l'activité des macrophages résidents du tissu dans un organe ou un tissu d'un animal nécessitant un traitement par une administration systémique d'un facteur stimulant les colonies. Par exemple, l'activité des cellules microgliales dérivées de la moelle osseuse dans un organe ou tissu peut être augmentée par une administration systémique d'un facteur stimulant les colonies, en particulier le facteur stimulant les colonies de macrophages, soit seul soit en association avec d'autres facteurs stimulant les colonies, des facteurs de cellules souches ou autres composés capables de traiter l'amyloïdose.

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