C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/20 (2006.01) A61K 38/30 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2155929
The present invention relates to methods of therapeutic or prophylactic treatment of connective tissue diseases by systemic or local delivery of a nucleic acid sequence to a mammalian host. Expression of the nucleic acid sequence results in the systemic delivery of a biologically active protein or peptide which acts to antagonize inflammatory, hypertrophic and erosive phenomenon associated with connective tissue disease. Systemic delivery of such gene products results in sustained treatment of connective tissue diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Méthodes de traitement thérapeutique et prophylactique d'affections des tissus conjonctifs par administration systémique ou locale d'une séquence d'acides nucléiques à un mammifère hôte. L'expression de la séquence d'acides nucléiques se traduit par la libération systémique d'une protéine ou d'un peptide biologiquement actif qui s'oppose aux phénomènes d'inflammation, d'hypertrophie ou d'érosion associés aux affections des tissus conjonctifs. La libération systémique de ces produits géniques permet un traitement soutenu des affections des tissus conjonctifs telles que l'arthrite rhumatoïde et le lupus érythémateux systémique.
Evans Christopher H.
Robbins Paul D.
Smart & Biggar
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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