Systems and compounds for drug delivery to interstitial...

Details Systems and compounds for drug delivery to interstitial... Systems and compounds for drug delivery to interstitial...

A - Human Necessities

61

M

A61M 31/00 (2006.01) A61K 9/127 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61N 1/05 (2006.01) A61B 17/00 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2347028

Catheter system (9) with centrally located drug delivery catheter (20) is adapted to be implanted at a depth within the left ventricular apex (15) of the heart (10). Hollow penetrating structure (30) penetrates the heart muscle from the endocardial side. The delivery catheter is navigated into the endorcardial space of the left ventricle (510), and secured in place with penetrating structure (30). A small dose of therapeutic agent, molecules (35), is injected into the myocardium, and the penetrating structure (30) is withdrawn. The molecules (35) of the therapeutic agent are taken up by the lymphatic system, entering into vessels (501, 502), transported upwardly; also migrate out of the lymphatic system, and into the coronary artery (505).

Un système cathéter (9), équipé d'un cathéter d'administration (20) de médicament en position centrale, permet une pénétration profonde dans la pointe ventriculaire gauche (15) du coeur (10). Une structure creuse pénétrante (30) permet une pénétration dans le muscle cardiaque du côté de l'endocarde. Le cathéter d'administration est déplacé dans l'espace endocardiaque du ventricule gauche (510), et fixé à l'aide de la structure pénétrante (30). Une petite dose de molécules (35) d'agent thérapeutique est injectée dans le myocarde, puis la structure pénétrante (30) est retirée. Les molécules (35) de l'agent thérapeutique sont emmenées par le système lymphatique, pénètrent dans les vaisseaux (501)(502), en étant transportées vers le haut; ces molécules quittent aussi le système lymphatique pour pénétrer dans l'artère coronaire (505).

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