Systems and methods for determining cross-talk coefficients...

Details Systems and methods for determining cross-talk coefficients... Systems and methods for determining cross-talk coefficients...

G - Physics

01

N

G01N 21/64 (2006.01) G01N 21/27 (2006.01) G06K 9/00 (2006.01)

Patent

CA 2691907

Systems and methods for determining cross-talk coefficients in curves, such as sigmoid-type or growth curves, and PCR curves and nucleic acid melting curves in particular, as well as for applying the cross-talk coefficients to produce cross-talk corrected data sets using a linear subtractive model. Cross-talk signal coefficients are determined using cross-talk data acquired across the entire signal acquisition range. Analyzing across all of the signal curve data provides for a more robust cross-talk correction across the entire data acquisition range. A linear subtractive model is used to correct data sets having cross-talk components.

La présente invention concerne des systèmes et des procédés pour déterminer des coefficients de cross-talk (chevauchement) dans des courbes, telles que des courbes de type sigmoïde ou de croissance, et en particulier des courbes PCR et des courbes de fusion d'acides nucléiques, ainsi que pour appliquer les coefficients de cross-talk (chevauchement) afin de produire des jeux de données de cross-talk (chevauchement) corrigées au moyen d'un modèle linéaire soustractif. Les coefficients de signaux de cross-talk (chevauchement) sont déterminés au moyen de données de cross-talk (chevauchement) acquises sur la totalité de la plage d'acquisition de signaux. L'analyse de la totalité des données de la courbe de signaux fournit une correction de cross-talk (chevauchement) plus robuste sur la totalité de la plage d'acquisition de données. Un modèle linéaire soustractif est utilisé pour corriger les jeux de données ayant des composantes de cross-talk (chevauchement).

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