Systems and methods for enrichment of analytes

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2622745

The invention relates to one or more size-based separation modules adapted to increase a concentration of a first analyte in a sample by at least 10,000 fold, wherein said first analyte has an initial concentration in said sample of less than 1 x 10 -3 analytes/~L, and an analyzer for analyzing said first analytes in an enriched medium. Methods of using the separation modules for identifying a characteristic associated with a condition in a patient e.g. a fetal abnormality are also provided.

L'invention concerne, d'une part, au moins un module de séparation basé sur la taille conçu pour accroître d'au moins 10000 fois une concentration d'un premier analyte dans un échantillon, ledit premier analyte possédant une concentration initiale dans cet échantillon inférieure à 1 x 10 -3 analytes/?L, et, d'autre part, un appareil d'analyse conçu pour analyser lesdits premiers analytes dans un milieu enrichi. Cette invention a aussi pour objet des méthodes d'utilisation des modules de séparation dans l'identification d'une caractéristique associée à un trouble chez un patient, par exemple, une anomalie foetale.

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