Systems and methods for freezing, mixing and thawing...

F - Mech Eng,Light,Heat,Weapons – 25 – D

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F25D 31/00 (2006.01) F25D 16/00 (2006.01) F25D 25/00 (2006.01)

Patent

CA 2498718

A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity (26) for receiving a container (10) for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces (28) facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable-contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable-contacting surface contacts the container. Also, the cavity may be configured to receive a frame (15) for supporting the container holding the biopharmaceutical material. Further, the system may include a driver (500) to move the frame holding the container inside the cavity.

L'invention concerne un système de congélation, de stockage et de décongélation maîtrisés d'un matériau biopharmaceutique comprenant une cavité de réception d'un récipient destiné au maintien du matériau biopharmaceutique. Ce système comprend aussi une paire de surfaces opposées faisant face au récipient de maintien du matériau biopharmaceutique. Au moins une des surface opposées comporte une surface de contact mobile conçue afin de rentrer en contact avec le récipient afin d'empêcher tout présence d'espace entre le récipient et cette surface. Il comprend encore au moins une surface de transfert de chaleur couplée thermiquement au récipient de maintien du matériau biopharmaceutique lorsque la surface de contact mobile est en contact avec le récipient. La cavité peut aussi être conçue afin de recevoir un cadre supportant le récipient contenant le matériau biopharmaceutique. Le système peut, en outre, comprendre un dispositif d'entraînement afin de déplacer le cadre maintenant le récipient à l'intérieur de la cavité.

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