Systems and methods for identifying diagnostic indicators

Details Systems and methods for identifying diagnostic indicators Systems and methods for identifying diagnostic indicators

G - Physics

01

N

G01N 33/48 (2006.01)

Patent

CA 2618939

Systems and methods are provided for predicting patient response to a therapy regimen for a liver disease or a disease that is treatable with an immunomodulatory disease therapy using gene expression classifiers. Systems and methods for screening for modulators of target gene expression are also provided. Systems and methods for developing therapeutics against one or more of the proteins coded for by genes of the present invention are also provided. Systems and methods for predicting a patient response to a regimen of pegylated interferon alpha and ribavirin in a therapy for hepatitis C viral infection are also provided.

L'invention concerne des systèmes et des procédés permettant de prédire la réaction d'un patient à un régime thérapeutique pour une maladie hépatique ou une maladie pouvant être traitée par un traitement immunomodulateur faisant intervenir des classificateurs d'expression de gènes. L'invention concerne également des systèmes et des procédés permettant de cribler des modulateurs d'expression de gènes cibles. L'invention concerne également des systèmes et des procédés permettant de développer des agents thérapeutiques contre une ou plusieurs protéines codées par lesdits gènes. L'invention concerne en outre des systèmes et des procédés permettant de prédire la réaction d'un patient à un régime d'interféron alpha pégylé et de ribavirine dans un traitement pour une infection par le virus de l'hépatite C.

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