Systems and methods for manufacturing liposomes

Details Systems and methods for manufacturing liposomes Systems and methods for manufacturing liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/43 (2006.01) A61K 39/00 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2616877

The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as a nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.

La présente invention porte sur un appareil et sur des procédés de fabrication de liposomes. En amenant une solution tampon dans un premier réservoir et une solution lipidique dans un second réservoir, la dilution continue de la solution lipidique avec la solution tampon dans une chambre de mélange permet d'obtenir un liposome. Un agent thérapeutique, tel qu'un acide nucléique, est inclus soit dans la solution tampon, soit dans la solution lipidique. On mélange les deux solutions de façon à produire sensiblement instantanément un liposome encapsulant le produit thérapeutique. Puis, la solution liposomique obtenue est immédiatement diluée avec la solution tampon afin d'obtenir une meilleure homogénéité et de conserver une petite granulométrie.

Affiliated with

Also associated with

Rating

Systems and methods for manufacturing liposomes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Systems and methods for manufacturing liposomes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systems and methods for manufacturing liposomes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1645305