G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 15/00 (2006.01) G01N 11/02 (2006.01) G01N 33/49 (2006.01)
Patent
CA 2660381
A method for measuring properties of a fluid including placing a quantity of fluid in a container; inducing flow in the fluid wherein the flow is substantially streamlined in at least a measuring region of the container by constricting flow, and wherein the fluid is recirculated through the measuring region. A mixing region can be created separate from the measuring region sufficient to substantially mix the fluid. Free stream particulates in the fluid can be measured in the streamlined region. The invention is of particular interest in the assessment of blood platelet function. The method provides specific localized regions of thorough mixing that enable reproducible platelet aggregation, and also provides specific localized regions of streamlined flow that enable certain modalities of assessing aggregation. Both of these regions of flow are induced such that damage to platelet aggregates and other blood components as well as undesirable agglomeration on device surfaces is minimized.
L'invention porte sur un procédé de mesure des propriétés d'un fluide consistant: à placer une quantité du fluide dans un récipient; et à créer par constriction dans le fluide un courant sensiblement laminaire dans au moins la zone de mesure, lequel courant recirculant dans ladite zone. On prévoit une zone de mélange distincte de la zone de mesure et permettant de mélanger le fluide. Les particules libres du courant sont mesurées dans la zone laminaire. L'invention présente un intérêt particulier pour ce qui est de l'évaluation des fonctions des plaquettes. Le procédé prévoit des zones localisées de mélange parfait permettant de reproduire les conditions d'agrégation des plaquettes et des zones localisées parfaitement laminaires offrant certaines modalités d'évaluation de l'agrégation. Ces deux zones sont conçues pour réduire les dommages aux agrégats plaquettaires et autres composants du sang, ainsi que l'agglomération non désirée sur les surfaces du dispositif.
Rhodes Johnny
Sukavaneshvar Sivaprasad
Thekkedath Ramachandran
Ridout & Maybee Llp
Thrombodyne Inc.
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