Systems and methods for measuring fluid properties

Details Systems and methods for measuring fluid properties Systems and methods for measuring fluid properties

G - Physics

01

N

G01N 33/00 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2520199

A method for measuring properties of a fluid including placing a quantity of fluid in a container (12); inducing flow in the fluid wherein the flow is substantially streamlined in at least a measuring region (28) of the container (12), and wherein the fluid is recirculated through the measuring region (28); creating a mixing region (26) separate from the measuring region (28) sufficient to substantially mix the fluid; and measuring a property of the fluid in the streamlined region (28). The invention is of particular interest in the assessment of blood platelet function. The method provides specific localized regions of thorough mixing that enable reproducible platelet aggregation, and also provides specific localized regions of streamlined flow that enable certain modalities of assessing aggregation. Both of these regions of flow are induced such that damage to platelet aggregates and other blood components is minimized.

L'invention concerne un procédé de mesure des propriétés d'un fluide, qui consiste à placer une quantité de fluide dans un récipient ; à induire un flux dans le fluide, flux sensiblement direct dans au moins une zone de mesure du récipient, et le fluide étant remis en circulation dans la zone de mesure ; à créer une zone de mélange séparée de la zone de mesure, suffisante pour permettre le mélange substantiel du fluide ; et à mesurer la propriété du fluide dans la zone de flux direct. Les systèmes et procédés de l'invention sont particulièrement intéressants dans l'évaluation de la fonction plaquettaire du sang. Le procédé permet la production de zones localisées spécifiques de mélange complet permettant l'agrégation plaquettaire reproductible, et de zones localisées spécifiques de flux direct permettant certaines modalités d'évaluation de l'agrégation. Ces zones de flux sont induites, de manière que les dommages aux agrégats plaquettaires et aux autres composants du sang soient réduits au minimum.

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