A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61K 31/00 (2006.01) A61K 31/167 (2006.01) A61K 38/48 (2006.01) A61K 38/55 (2006.01) A61K 45/06 (2006.01) C07C 69/76 (2006.01)
Patent
CA 2385488
The invention provides methods to treating an obstructed biological conduit, that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes preventively dilating a section of conduit to minimize the risk of obstruction formation.
La présente invention concerne des techniques permettant de traiter une voie biologique obstruée, qui consiste à administrer dans cette voie un agent qui peut dégrader la matrice extracellulaire du tissu obstrué. Des techniques particulières consistent à déposer une enzyme ou un mélange de plusieurs enzymes sur la zone ou la région obstruée, ces enzymes étant capable de dégrader les composants de la matrice extracellulaire dans la partie obstruée, restorant ainsi l'écoulement normal du fluide transporté à travers cette voie. Cette invention consiste aussi à dilater préventivement une partie de la voie de façon à minimiser le risque de récidive.
Johns Hopkins University
Proteon Therapeutics Inc.
Ridout & Maybee Llp
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