Systems and methods for reversibly blocking nerve activity

A - Human Necessities – 61 – N

Patent

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A61N 1/34 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2438541

A system and method for blocking nerve impulses using an implanted electrode located on or around a nerve. A specific waveform (34) is used that causes the nerve membrane to become incapable of transmitting an action potential. The waveform has a first phase (36) that produces subthreshold depolarization of the nerve membrane, and a second phase (38) having a shorter duration. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic condition. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.

L'invention concerne des systèmes et des procédés de blocage d'impulsions nerveuses qui utilisent une électrode implantée placée sur ou autour d'un nerf. On utilise une forme d'onde spécifique qui rend la membrane nerveuse incapable de transmettre un potentiel actif. La membrane n'est affectée que sous l'électrode et l'effet est immédiatement et complètement réversible. La forme d'onde possède une faible amplitude et peut être équilibrée en charge avec une forte probabilité d'être sans danger pour le nerf dans des conditions chroniques. On peut bloquer à loisir le plus grandes fibres nerveuses (moteur) au sein d'un nerf mixte, tout en permettant à des informations sensorielles de voyager par des fibres nerveuses non-affectées.

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