Systems and methods for screening pharmaceutical chemicals

C - Chemistry – Metallurgy – 12 – N

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C12N 5/00 (2006.01) C12N 5/071 (2010.01) C12M 1/34 (2006.01) C12M 3/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 3/00 (2006.01) G01N 3/02 (2006.01) G01N 3/38 (2006.01)

Patent

CA 2497343

A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and hysteresis.

L'invention concerne un procédé permettant d'obtenir une réponse d'un système modèle de tissu d'un activateur. Ce procédé consiste à mettre en contact un système modèle de tissu bio artificiel avec un activateur et à mesurer le réponse mécanique cellulaire d'au moins une force contractile et la rigidité du tissu. Ce procédé permettant d'obtenir une réponse d'un système modèle de tissu d'un activateur consiste à mettre en contact un système modèle de tissu bio artificiel avec un activateur et à mesurer la réponse mécanique cellulaire d'au moins une force contractile et l'hystérésis.

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