Systems and methods for separating high hematocrit red blood...

A - Human Necessities – 61 – K

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A61K 35/14 (2006.01) A01N 1/02 (2006.01) A61M 1/30 (2006.01) A61M 1/34 (2006.01) B01D 63/06 (2006.01) A61M 1/26 (2006.01)

Patent

CA 2198696

Blood separation systems and methods utilize a membrane separation device (52) comprising a gap (60) between a microporous membrane (64) and a surface (56) facing the microporous membrane (64), one of the microporous membrane (64) and the surface (56) being rotatable relative to the other to cause separation of whole blood in the gap (60) into plasma and concentrated red blood cells. The systems and methods include an inlet pump element (20) and a drive element (46) coupled to the membrane separation device (52) and the steps of commanding the inlet pump element (20) and the drive element (46) as a function of the known beginning hematocrit value to obtain concentrated red blood cells having a high end hematocrit value that remains substantially constant despite variances in the known beginning hematocrit value.

L'invention concerne des systèmes et des procédés de séparation du sang, dans lesquels on utilise un dispositif de séparation (52) à membrane comprenant un espace (60) prévu entre une membrane microporeuse (64) et une surface (56) en regard de celle-ci (64), la membrane microporeuse (64) ou la surface (56) étant rotative par rapport à l'autre de sorte que la séparation de sang entier en plasma et en globules rouges concentrés soit induite dans ledit espace (60). Lesdits systèmes comprennent une pompe d'entrée (20) et un élément d'entraînement (46) accouplés au dispositif de séparation (52) à membrane, et les procédés consistent à commander la pompe d'entrée (20) et l'élément d'entraînement (46) en fonction de la valeur de l'hématocrite de départ connue de sorte que des globules rouges concentrés présentant une valeur d'hématocrite finale élevée restant sensiblement constante quelles que soient les variations de la valeur de l'hématocrite de départ connue, soient produits.

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