Systems and methods of blood-based therapies having a...

B - Operations – Transporting – 01 – D

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B01D 43/00 (2006.01) B01L 99/00 (2010.01) A61M 1/14 (2006.01) A61M 1/36 (2006.01) G01N 33/49 (2006.01)

Patent

CA 2518667

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

L'invention concerne des dispositifs, des systèmes et des procédés destinés à éliminer des matériaux indésirables dans un échantillon fluidique par mise en contact avec un second fluide. L'échantillon fluidique s'écoule en couche mince à proximité ou entre, simultanément des couches d'écoulement du second fluide, sans membrane d'intervention. Dans divers modes de réalisation, un séparateur secondaire est utilisé en vue de restreindre l'élimination des substances désirables et produire l'élimination des substances indésirables dans le sang. L'invention est utile dans une variété de situations dans lesquelles un échantillon fluidique doit être purifié via un mécanisme de diffusion contre un fluide extracteur. En outre, l'invention peut être utilisée en vue d'éliminer des composants d'un échantillon fluidique qui varient en dimension. Lorsque le sang se révèle être l'échantillon fluidique, par exemple, l'élimination peut porter sur des <=petites >= molécules, des molécules <= moyennes >=, des macromolécules, des agrégats macromoléculaires, et des cellules, à partir de l'échantillon sanguin vers le fluide extracteur.

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