Systems, methods and computer program products for guiding...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/09 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2427624

Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen or a preventive therapeutic treatment regimen are disclosed. The method comprises (A) providing to a computing device comprising a first knowledge base comprising information about a plurality of different methylation statuses at selected sites of the DNA in cells with a known disease or medical condition and/or healthy cells, a second knowledge base comprising a plurality of expert rules for evaluating and selecting a type of disease or medical condition based on the methylation status at selected sites of the DNA of a patient, (B) generating in said computing device a ranked listing of diseases or medical conditions based on the information about the methylation status at selected sites of the DNA of the patient, the first knowledge base and the second knowledge base.

La présente invention concerne des systèmes, des procédés et progiciels d'assistance dans le choix d'un schéma posologique prophylactique ou thérapeutique. A cet effet, on commence par (A) fournir à un dispositif infirmatique comprenant d'une part une première base de connaissance comprenant de l'information au sujet d'une pluralité d'états différents de méthylation en des sites sélectionnés de l'ADN de cellules affectées d'un état mathologique ou médical connu et/ou de cellules saines, et d'autre part une seconde base de connaissance comprenant une pluralité de règles expertes permettant d'évaluer et de sélectionner un type d'état pathologique ou médical sur la base de l'état de méthylation aux sites sélectionnés de l'ADN d'un patient, puis (B) on génère dans ledit dispositif informatique une liste d'états pathologiques ou médicaux classée sur la base de l'information au sujet de l'état de méthylation au niveau des sites sélectionnés de l'ADN du patient, de la première base de connaissance et de la seconde base de connaissance.

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