T-bet compositions and methods of use thereof

Details T-bet compositions and methods of use thereof T-bet compositions and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2375050

Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.

L'invention concerne des molécules d'acide nucléique codant T-bet et des protéines T-bet isolées. Elle concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinants contenant une molécule d'acide nucléique de l'invention, des cellules hôtes dans lesquelles ces vecteurs d'expression ont été introduits, et des animaux transgéniques non humaines porteurs du transgène T-bet. L'invention concerne en outre des protéines de fusion T-bet et des anticorps anti-T-bet, ainsi que des méthodes d'utilisation des compositions T-bet, notamment des méthodes de détection de l'activité de T-bet dans un échantillon biologique, des méthodes de modulation de l'activité de T-bet dans une cellule, et des méthodes d'identification d'agents modulant l'activité de T-bet.

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