T-cadherin adhesion molecule

Details T-cadherin adhesion molecule T-cadherin adhesion molecule

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2095115

2095115 9208731 PCTABS00013 The invention provides substantially purified T-cadherin polypeptides and isolated nucleic acids which encode the T-cadherin polypeptides. Antibodies reactive with various forms of T-cadherin, but not reactive with N-, E- or P-cadherin are also provided. The invention provides methods for detecting the various forms of T-cadherin in a subject as well as a method of inhibiting tumor cell migration which consists of increasing tumor cell adhesion with an effective amount of T-cadherin. A method of repairing traumatized neurons is provided. The method entails treating traumatized neurons with a therapeutically effective dose of T-cadherin.

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