C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/725 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2210812
The present invention provides peptides which affect T-cells, presumably by action on the T-cell antigen receptor. The present invention further relates to the therapy of various inflammatory and autoimmune disease states involving the use of these peptides. Specifically, the peptides are useful in the treatment of disorders where T- cells are involved or recruited. The peptide is of the following formula: A-B-C-D-E in which: A is absent or 1 or 2 hydrophobic amino acids, B is a positively charged amino acid, C is a peptide consisting of 3 to 5 hydrophobic amino acids, D is a positively charged amino acid, and E is absent or up to 8 hydrophobic amino acids.
La présente invention concerne des peptides qui influent sur les lymphocytes T, vraisemblablement par action sur le récepteur antigénique des lymphocytes T. La présente invention concerne en outre un traitement utilisable contre différentes maladies inflammatoires et auto-immunes faisant appel à ces peptides. Plus précisément, les peptides sont utiles pour le traitement de troubles qui sont provoqués ou dans lesquels sont impliqués les lymphocytes T. Le peptide a la formule A-B-C-D-E, dans laquelle A est absent ou correspond à un ou deux acides aminés hydrophobes, B est un acide aminé chargé positivement, C est un peptide constitué de 3 à 5 acides aminés hydrophobes, D est un acide aminé chargé positivement et E est absent ou comprend jusqu'à 8 acides aminés hydrophobes.
Northern Sydney And Central Coast Area Health Service
Northern Sydney Area Health Services
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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