T cell assays

Details T cell assays T cell assays

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2644540

The present invention relates to novel T cell assay methods, in particular where T cell responses to test antigens are increased by removal of regulatory T cells. Novel assays where the timing of incubation with antigens or other samples is varied in order to optimize detection of T cell responses are described. The invention has particular application for measurement of human T cell responses to pharmaceuticals, allergens, irritants or other substances.

L'invention concerne de nouveaux procédés de dosage de lymphocytes T, notamment des procédés dans lesquels des réactions de lymphocytes T à des antigènes d'essai sont augmentées par élimination de lymphocytes T régulateurs. L'invention concerne également de nouveaux dosages dans lesquels le temps d'incubation avec des antigènes ou d'autres échantillons varie afin d'optimiser la détection des réactions des lymphocytes T. Cette invention est particulièrement utile dans la mesure des réactions des lymphocytes T humains à des produits pharmaceutiques, des allergènes, des irritants et à d'autres substances.

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