T-cell cytokine-inducing surface molecules and methods of use

Details T-cell cytokine-inducing surface molecules and methods of use T-cell cytokine-inducing surface molecules and methods of use

A - Human Necessities

61

K

A61K 31/5377 (2006.01) A61K 31/4174 (2006.01) A61K 31/4184 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/713 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C12N 5/0783 (2010.01)

Patent

CA 2689124

The invention provides cytokine modulators and methods for using the same to modulate cytokine production in monocyte lineage-derived cells. In particular, cytokine modulators of the invention selectively bind to a T-cell cytokine-inducing surface molecule (TCISM)-ligand of T lymphocytes or the corresponding TCISM-receptor of monocyte lineage-derived cells, thereby modulating cytokine production in monocyte lineage-derived cells.

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