T-cell epitodes in carboxypeptidase g2

Details T-cell epitodes in carboxypeptidase g2 T-cell epitodes in carboxypeptidase g2

A - Human Necessities

61

K

A61K 38/48 (2006.01) C12N 9/48 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2468501

The invention in particular relates to the modification of a bacterial enzyme carboxypeptidease G2 (CPG2) to result in CPG2 proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The present invention relates also to T-cell epitope peptides derived from said non-modified protein by means of which it is possible to create modified CPG2 variants with reduced immunogenicity. These polypeptides are suitable particularly for therapeutic use in humans.

L'invention concerne la modification d'une carboxypeptidease G2 (CPG2) d'une enzyme bactérienne en protéines CPG2 qui sont pratiquement non immunogènes ou moins immunogènes que tout homologue non modifié, lors d'une utilisation in vivo. Cette invention a également trait à des peptides d'épitopes de lymphocytes T dérivés de ladite protéine non modifiée, au moyen desquels il est possible de créer des variants CPG2 modifiés à immunogénicité réduite. Ces polypeptides sont notamment appropriés à une utilisation thérapeutique chez des êtres humains.

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