C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/415 (2006.01) A61K 39/36 (2006.01) C07K 7/08 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2258125
The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen allergy with an overlap peptide covering the primary structure of the Japanese cypress pollen allergen. The peptide is useful in peptide-based immunotherapy for patients with spring tree pollinosis including patients with Japanese cypress pollinosis having cross reactivity with Japanese cypress pollen. The peptide is also useful for diagnosing spring tree pollinosis.
On a identifié le site antigène Ly sur une molécule allergène propre à la pollinose du cyprès japonais (hinoki) en stimulant une lignée cellulaire de lymphocyte T chez un patient souffrant de cette pollinose, par l'intermédiaire d'un peptide chevauchant qui couvre la structure primaire de l'allergène dans le pollen de l'hinoki. Ce peptide contribue à l'immunothérapie ou au diagnostic des pollinoses d'arbre au printemps, y compris la pollinose de l'hinoki, en cas de réactivité croisée avec le pollen du cyprès japonais.
Dairiki Kazuo
Kino Kohsuke
Meiji Co. Ltd.
Meiji Milk Products Co. Ltd.
Smart & Biggar
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