T cell epitopes of ryegrass pollen allergen

Details T cell epitopes of ryegrass pollen allergen T cell epitopes of ryegrass pollen allergen

C - Chemistry, Metallurgy

12

N

C12N 15/29 (2006.01) A61K 39/35 (2006.01) C07K 14/415 (2006.01) C07K 14/725 (2006.01) C07K 16/16 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2157596

The present invention provides isolated peptides of Lol p I, a major protein allergen of the species Lolium perenne. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p I. The invention also provides modified peptides having similar or enhanced therapeutic or diagnostic properties as the corresponding naturally-occurring allergen or portion thereof, but having additional properties, e.g., reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment and diagnosis of treatment to Lol p I or an allergen immunologically related to Lol p I in an individual (such as Dac g I Poa p I or Phl p I) also are provided. Compositions for therapeutic, diagnostic or reagent uses comprising one or more peptides of the invention are also provided.

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