T cell epitopes of the major allergens from dermatophagoides...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 39/35 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2121497

The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der .function. I, or Der .function. II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally- occurring allergen or portion thereof, but having seduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

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