T cell growth factor

Details T cell growth factor T cell growth factor

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2050477

The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-respon- sive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical composi- tions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for in- ducing the proliferation of helper T cells as well as IL3- and IL4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.

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