T cell inhibitory receptor compositions and uses thereof

Details T cell inhibitory receptor compositions and uses thereof T cell inhibitory receptor compositions and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2328725

The invention relates to compositions which bind T cell inhibitory receptor molecules and modulate T cell activity, and methods of using such compositions. Such compositions include biliary glycoprotein binding agents. Methods for modulating killer T cell activities, including cytotoxicity and proliferation also are provided.

La présente invention concerne des compositions qui créent une liaison avec les molécules de récepteurs inhibiteurs de lymphocytes T et qui modulent l'activité du lymphocyte T. L'invention concerne également l'utilisation de telles compositions. Ces compositions contiennent des agents de liaison de la glycoprotéine biliaire. L'invention concerne enfin des procédés permettant une modulation des activités des lymphocytes T tueurs, et notamment leur cytotoxicité et leur prolifération.

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