T cell receptor cdr3 sequences and methods for detection

Details T cell receptor cdr3 sequences and methods for detection T cell receptor cdr3 sequences and methods for detection

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) C07K 14/725 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2485874

The present invention relates generally to the field of treating autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA) and others. Methods of treating and monitoring an autoimmune disease by utilizing T-cell receptors peptides are disclosed. Nucleic acid and peptide sequences of T-cell receptors found in a population of MS patients are also disclosed.

L'invention se situe, d'une manière générale, dans le domaine du traitement des maladies auto-immunes, telles que la sclérose en plaques (MS), la polyarthrite rhumatoïde (RA) et analogues. L'invention concerne des méthodes de traitement et de surveillance d'une maladie auto-immune consistant à utiliser des peptides des récepteurs des lymphocytes T. L'invention concerne enfin des séquences d'acides nucléiques et de peptides des récepteurs des lymphocytes T découvertes dans une population de patients atteints de la sclérose en plaques.

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