T cell receptor peptides as therapeutics for autoimmune and...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/02 (2006.01) A61K 35/26 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12N 5/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2064077

Peptides and pharmaceutical compositions comprising immunogenic peptides of a marker T cell receptor (TCR) character- istic of an immune-related disease, capable of preventing, suppressing, or treating the disease, are disclosed. In a preferred em- bodiment, the amino acid sequence of the peptide corresponds to at least part of a complementary determining region (CDR) or a hypervariable region of the TCR. Antibodies and/or T cells immunologically reactive to the TCR peptide capable of preventing, suppressing, or treating an immune-related disease by passive transfer are also disclosed.

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