T-cell receptor variable transcripts as disease related markers

Details T-cell receptor variable transcripts as disease related markers T-cell receptor variable transcripts as disease related markers

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 35/12 (2006.01) A61K 35/18 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2081672

2081672 9117268 PCTABS00008 Methods are provided for determining relations between autoimmune degenerative diseases and specific variable regions of T-cell receptors as associated with the host HLA or T-cells associated with combatting neoproliferative diseases. By identifying the particular T-cell receptors which cause or are the disease in mammals, various prophylactic and therapeutic techniques may be employed for inhibiting the attack of the T-cell receptors on the native protein or tissue enhancing the defense. In addition, individuals may be diagnosed as to their propensity for a particular autoimmune disease or the occurrence of such a disease.

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