T cell receptors and related materials and methods of use

Details T cell receptors and related materials and methods of use T cell receptors and related materials and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2734838

The invention provids an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

La présente invention concerne un récepteur de lymphocyte T isolé ou purifié (TcR) ayant une spécificité antigénique pour un antigène du cancer, par exemple un antigène du carcinome à cellules rénales, le TcR reconnaissant lantigène du cancer dans un complexe majeur dhistocompatibilité (MHC) de manière indépendante. Linvention concerne également des matériaux associés comme des polypeptides, des protéines, des acides nucléiques, des vecteurs dexpression recombinés, des cellules hôtes isolées, des populations de cellules, des anticorps, ou des parties de liaison à lantigène de ceux-ci, et des compositions pharmaceutiques. Linvention concerne en outre un procédé de détection de la présence dun cancer dans un hôte et un procédé de traitement ou de prévention dun cancer dans un hôte en utilisant les TcR ou les matériels associés de linvention.

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