T-cell receptors and their use in therapeutic and diagnostic...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/10 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) C07K 14/725 (2006.01) C07K 14/735 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2217009

The present invention provides nucleic acid sequences for T-cell receptors which recognize tumor associated antigens. In particular, T-cell receptors which recognize melanoma antigens. This invention also provides T-cells expressing the antigen specific T-cell receptors. In addition, this invention provides stem cells expressing the antigen specific T-cell receptors or chimeric receptors. This invention further relates to therapeutic and diagnostic compositions and methods employing the T-cell receptors and chimeric receptors provided herein.

La présente invention décrit des séquences d'acide nucléique pour des récepteurs des lymphocytes T qui reconnaissent des antigènes associés aux tumeurs, et notamment des récepteurs des lymphocytes T qui reconnaissent les antigènes des mélanomes. La présente invention décrit également des lymphocytes T exprimant les récepteurs de lymphocytes T spécifiques d'antigènes. De plus, elle décrit des cellules souches exprimant les récepteurs de lymphocytes T spécifiques d'antigènes ou récepteurs chimères. Elle concerne également des compositions et méthodes thérapeutiques et diagnostiques utilisant les récepteurs des lymphocytes T et les récepteurs chimères décrits ici.

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