T cell regulatory genes and methods of use thereof

Details T cell regulatory genes and methods of use thereof T cell regulatory genes and methods of use thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2452196

A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.

L'invention concerne un locus génétique ainsi que la famille de protéines correspondante associés à la régulation de la fonction immunitaire et à la survie des cellules. Lesdits gènes codent les molécules de surfaces des cellules au moyen de domaines conservés d'immunoglobuline V et de mucine. Ledit locus comprenant la famille TIM est associé génétiquement à un dysfonctionnement immunitaire, y compris l'asthme. De plus, la famille de gènes TIM est située à l'intérieur d'une région du chromosome humain 5 qui est fréquemment délété dans des tumeurs malignes et dans le syndrome myélodysplatique. Des polymorphismes dans les séquences de gènes sont associés au développement d'une hyperréactivité bronchique et des inflammations allergiques, et à une production de lymphocytes T d'IL 4 et IL 3. Les protéines comportent le récepteur cellulaire humain de l'hépatite A, hHAVcr-1.

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