T-lymphocyte progenitor cell assay

Details T-lymphocyte progenitor cell assay T-lymphocyte progenitor cell assay

C - Chemistry, Metallurgy

12

Q

C12Q 1/04 (2006.01) C12Q 1/24 (2006.01) G01N 33/48 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2063578

2063578 9116451 PCTABS00008 Methodology is provided for identifying the presence of human T-lymphocyte progenitor cells. Human thymus tissue is depleted of endogenous lymphoid cells, repopulated with a human cellular composition which is HLA mismatched with the thymus tissue and implanted into a vascularizable site in an immunocompromised host. After at least about two weeks, the tissue may be assayed for the presence of the HLA mismatched T-lymphocytes as indicative of human T-lymphocyte progenitors in this cellular composition.

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