T-pa pro stabilisation

Details T-pa pro stabilisation T-pa pro stabilisation

A - Human Necessities

61

K

A61K 38/49 (2006.01) A61K 47/00 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2046929

Pharmaceutical preparation of a non-glycosylated t-PA with an enzymatic activity of at least 0.1 MU/ml. and a pH value of 4.5 to 6, which contains citrate and at least one compound of the group consisting of a) ascorbic acid, b) EDTA, c) amino compounds of the formula R1R2N - R - X whereby X = SO3H, CH(NH2)-CO2H, SO2H, H, NH2 or OH, R = C1-C9-alkylene, C3-C6-cycloalkylene or benzylidene and R1 and R2, independently of one another, are H or C1-C3-alkyl, d) guanidinobutyric acid, e) dimethylbiguanide, f) arginine, g) glucosamine, fructose, h) pyrimidine nucleosides and pyrimidine nucleotides, i) carboxylic acids substituted with one or more hydroxyl, keto and/or further carboxyl groups, as well as a medicament based on a non-glycosylated t-PA as active material and processes for its production.

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