A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61P 7/10 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 25/04 (2006.01) A61P 25/08 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2547235
A T-type calcium channel inhibitor which is any of a compound represented by the formula (1): [Chemical formula 1] (1) [wherein Ar1 means phenyl, pyridyl, furyl, or 2,1,3-benzoxadiazol-4-yl; the nitrogenous heterocycle moiety is a 1,4-dihydropyridine ring or pyridine ring; Z means the formula (2): [Chemical formula 2] (2) or CO2R2; Ra and Rb each independently means C1-6 alkyl, ANR8R9, CH2OANR8R9, etc.; when the nitrogenous heterocycle means a 1,4- dihydropyridine ring, then R1 means C1-6 alkyl, ANR8R9, AN(CH2CH2)2NR8, AN(CH2CH2)2O, AOR8, or benzyl; and R3 means hydrogen, C1-20 alkyl, ANR8R9, or a group represented by any of the following formulae], [Chemical formula 3] a pharmaceutically acceptable salt of the compound, and a solvate of either.
La présente invention a trait à un inhibiteur calcique de type T qui est un quelconque parmi un composé de formule (1), dans laquelle : Ar?1¿ représente phényle, pyridyle, furyle, ou 2,1,3-benzooxadiazol-4-yle ; le groupe fonctionnel hétérocyclique azoté est un noyau 1,4-dihydropyridine ou un noyau pyridine ; Z représente la formule (2) ou CO¿2?R?2¿; R?a¿ et R?b¿ sont indépendamment alkyle en C¿1?-C¿6?, ANR?8¿R?9¿, CH¿2?OANR?8¿R?9 ¿; lorsque l'hétérocycle azoté représente un noyau 1,4-dihydropyridine, alors R?1¿ représente alkyle en C¿1?-C¿6?, ANR?8¿R?9¿, AN(CH¿2?CH¿2?)¿2?NR?8¿, AN(CH¿2?CH¿2?)¿2?O, AOR?8¿, ou benzyle ; et R?3¿ représente hydrogène, alkyle en C¿1?-C¿20?, ANR?8¿R?9¿, ou un groupe représenté par une quelconque des formules (3) ; ou un sel pharmaceutiquement acceptable du composé et un solvate de l'un ou de l'autre.
Furukawa Taiji
Masuda Yukinori
Matsumoto Hiroo
Yamada Osamu
Yamashita Toru
Gowling Lafleur Henderson Llp
Nissan Chemical Industries Ltd.
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