C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/03 (2006.01)
Patent
CA 2576191
The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein R1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; Z is NH, NCH3, O, S, or CH2; Y is NH, O, or CH2 with the proviso that Y and Z are not the same; R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m + n = an integer ranging from 2-9; and R3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.
La présente invention concerne des nouveaux canaux calcium de type T représentés par la formule (I), et l'utilisation de ces inhibiteurs pour le traitement, chez un mammifère, d'une maladie ou d'un état associé à l'afflux de calcium extracellulaire via des canaux calcium de type T. Dans cette formule, R1 est C1-C4 alkyle, hydroxy, ou C1-C4 alkoxy; Z est NH, NCH3, O, S, ou CH2; Y est NH, O, ou CH2 à condition que Y et Z ne soient pas identiques; R2 est H, halo, NH2, C1-C4 alkyle, hydroxy, ou C1-C4 alkoxy; m et n sont choisis indépendamment parmi des entiers compris entre 1 et 5 sous réserve que m + n = un entier compris entre 2 et 9; et R3 est H, halo, NH2, C1-C4 alkyle, hydroxy, ou C1-C4 alkoxy.
Gray Lloyd S.
Haverstick Doris M.
Macdonald Timothy L.
Mccalmont William F.
Patterson Jaclyn R.
Mcfadden Fincham
University Of Virginia Patent Foundation
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