C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2566041
Cell proliferative conditions are associated with expression of a previously unknown Cav3.1 T-type calcium channel splice variant, Cav3.1ac. Also, it has been determined that the Cav3.1ac T-type splice variant interacts with annexin III (ANX III). This interaction is useful in identifying substances to treat cell proliferation. Also, diagnostics and prognostics of cell proliferative disorders and methods for treating such disorders are disclosed.
Les troubles pathologiques liés à la prolifération cellulaire sont associés à l'expression d'un variant d'épissage des canaux calciques de type T Ca¿v?3.1, qui était inconnu auparavant, à savoir Ca¿v?3.1ac. En outre, il a été établi que le variant d'épissage de type T Ca¿v?3.1ac interagissait avec l'annexine III (ANX III). Ladite interaction est utile pour identifier des substances permettant de traiter la prolifération cellulaire. L'invention concerne aussi des méthodes de diagnostic et de pronostic de troubles liés à la prolifération cellulaire, et des méthodes de traitement de tels troubles.
Hamid Jawed
Latour Isabelle
Mcrory John E.
Zamponi Gerald W.
Fetherstonhaugh & Co.
Hamid Jawed
Latour Isabelle
Mcrory John E.
Neuromed Pharmaceuticals Ltd.
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