T1 receptor-like ligand ii and uses thereof

Details T1 receptor-like ligand ii and uses thereof T1 receptor-like ligand ii and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2392742

The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.

L'invention concerne une nouvelle protéine-ligand II de type récepteur T1 (T1R). L'invention concerne notamment des molécules isolées d'acide nucléique codant pour la protéine-ligand II de type T1R. L'invention concerne également des polypeptides ligand II de type T1R, ainsi que des vecteurs recombinants et des cellules hôtes destinés à exprimer ces polypeptides. L'invention concerne par ailleurs des compositions pharmaceutiques et des formulations comprenant un ligand II de type T1R, ainsi que des procédés d'utilisation de polynucléotides, de polypeptides, des anticorps ou des agonistes/antagonistes ligand II de type T1R à des fins thérapeutiques et diagnostiques. L'invention concerne enfin des kits de diagnostic.

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