T1r taste receptors and genes encoding same

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2433514

Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

L'invention concerne des récepteurs couplés aux protéines G spécifiques de cellules gustatives de mammifère, ainsi que les gènes et l'ADNc codant ces récepteurs. Elle concerne spécifiquement des récepteurs T1R couplés aux protéines G qui sont actifs dans la signalisation du goût, les gènes et l'ADNc qui les codent ainsi que des procédés d'isolement de tels gènes et d'isolement et d'expression de tels récepteurs. Elle concerne aussi des procédés de représentation de la perception gustative d'un stimulus de goût particulier chez un mammifère, des procédés de production de molécules ou de combinaison de molécules qui provoquent une perception gustative déterminée chez un mammifère ainsi que des procédés de simulation d'un ou plusieurs goûts. Elle concerne enfin des procédés de simulation ou de blocage de perception gustative chez un mammifère.

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