C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.10
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/73 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1340627
A single-stranded nucleic acid molecule which encodes an animo acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These animo acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4+ cells. Monoclonal antibodies directed to the water-soluble ammo acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
544986
Axel Richard
Chess Leonard
Littman Dan J.
Maddon Paul J.
Mcdougal Steven
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
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