Tablet coating based on a melt-spun mixture of a saccharide...

A - Human Necessities – 61 – K

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A61K 9/28 (2006.01)

Patent

CA 2164344

A method for coating pharmaceutical tablets is disclosed in which polymeric coating ingredients an combined with saccharides in a melt spinning operation to form composite particulates. The particulates are then dispersed in water to form an aqueous polymer coating solution, followed by application to pharmaceutical tablets by such methods as spray coating. The particulates dissolve extremely rapidly in water to form a dispersion of the polymer coating ingredients. Such rapid dissolution allows for increased processing rates and avoids disadvantages of the prior art such as the requirement of high shear rate mixing for long times.

L'invention se rapporte à un procédé d'enrobage de comprimés pharmaceutiques au moyen duquel des ingrédients polymères d'enrobage sont mélangés avec des saccharides, par un processus de filage en fusion, afin d'obtenir des matières particulaires composites. Ces matières particulaires sont ensuite dispersées dans l'eau pour former une solution d'enrobage polymère aqueuse qui est appliquée sur des comprimés pharmaceutiques au moyen de ces procédés de revêtement par projection. Les matières particulaires se dissolvent extrêmement rapidement dans l'eau pour former une dispersion des ingrédients polymère d'enrobage. Une dissolution aussi rapide permet d'augmenter les vitesses de traitement et d'éviter les désavantages de la technique antérieure qui exige des temps de mélange longs, à des vitesses de cisaillement élevées.

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